Ro 90-7501

Name: Ro 90-7501
Brand: Tocris Bioscience
SKU: 2408

Tocris Bioscience, part of Bio-Techne | Catalog # 2408

Citations (2)

COA / SDS

Inhibitor of Aβ42 fibril formation

Key Product Details

Description:	Inhibitor of Aβ42 fibril formation
Chemical Name:	2'-(4-Aminophenyl)-[2,5'-bi-1H-benzimidazol]-5-amine
Purity:	≥98% (HPLC)
Molecular Weight:	340.39

View Full Technical Details for Ro 90-7501

Technical Data
Citations

Biological Activity for Ro 90-7501

Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC₅₀ = 2 μM).

Compound Libraries for Ro 90-7501

Ro 90-7501 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 90-7501

M. Wt	340.39
Formula	C₂₀H₁₆N₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	293762-45-5
PubChem ID	824226
InChi Key	PAGZCEHLFCJSPV-UHFFFAOYSA-N
Smiles	NC1=CC=C(C=C1)C1=NC2=CC=C(C=C2N1)C1=NC2=CC=C(N)C=C2N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 90-7501

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	3.4	10
	DMSO	34.04	100

Preparing Stock Solutions for Ro 90-7501

The following data is based on the product molecular weight 340.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.94 mL	14.69 mL	29.38 mL
5 mM	0.59 mL	2.94 mL	5.88 mL
10 mM	0.29 mL	1.47 mL	2.94 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for Ro 90-7501

References are publications that support the biological activity of the product.

Bohrmann Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J.Struct.Biol. 2000 PMID: 10940228