Rosiglitazone

Name: Rosiglitazone
Brand: Tocris Bioscience
SKU: 5325

Tocris Bioscience, part of Bio-Techne | Catalog # 5325

(1)

Citations (48)

COA / SDS

Potent and selective PPARγ agonist; antidiabetic agent

Key Product Details

Chemical Name:	5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for Rosiglitazone

Rosiglitazone is a potent and selective PPARγ agonist (EC₅₀ = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Technical Data for Rosiglitazone

Formula	C₁₈H₁₉N₃O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	122320-73-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rosiglitazone

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Rosiglitazone

References are publications that support the biological activity of the product.

KP Ganti, A Mukherji, M Surjit, M Li, P Chambon Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. 2017 PMID: 28115699
Lehmann et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem., 1995;270:12953 PMID: 7768881
Willson et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem., 1996;39:665 PMID: 8576907
Santos et al. Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun., 2019;10:4407 PMID: 31562298

Rosiglitazone

Tocris Bioscience, part of Bio-Techne | Catalog # 5325

Key Product Details

Biological Activity for Rosiglitazone

Technical Data for Rosiglitazone

Solubility for Rosiglitazone

Dilution Calculator

Reconstitution Calculator

References for Rosiglitazone

Product Documents for Rosiglitazone

COA

Certificate of Analysis

SDS

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