Rotigotine hydrochloride

Name: Rotigotine hydrochloride
Brand: Tocris Bioscience
SKU: 3896

Tocris Bioscience, part of Bio-Techne | Catalog # 3896

COA / SDS

D2 and D3 agonist

Key Product Details

Description:	D₂ and D₃ agonist
Alternative Names:	N 0923
Chemical Name:	(6S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	351.93

View Full Technical Details for Rotigotine hydrochloride

Technical Data
Citations

Biological Activity for Rotigotine hydrochloride

Rotigotine hydrochloride is a dopamine D₂ and D₃ receptor agonist. K_i values are 13 and 0.71 nM for D₂ and D₃ respectively. Also has significant affinity for 5-HT_1A and adrenergic α_2B receptors. Exhibits antiparkinsonian acitivity.

Compound Libraries for Rotigotine hydrochloride

Rotigotine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rotigotine hydrochloride

M. Wt	351.93
Formula	C₁₉H₂₅NOS.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	125572-93-2
PubChem ID	59226
InChi Key	CEXBONHIOKGWNU-NTISSMGPSA-N
Smiles	CCCN(CCC3=CC=CS3)[C@H]2CCC1=C(O)C=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rotigotine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.19	100

Preparing Stock Solutions for Rotigotine hydrochloride

The following data is based on the product molecular weight 351.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.41 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for Rotigotine hydrochloride

References are publications that support the biological activity of the product.

Belluzzi N-0923, a selective DA D₂ receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.Disord. 2004 PMID: 7910948
Scheller The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 2009 PMID: 18704368