RP 001 hydrochloride

Name: RP 001 hydrochloride
Brand: Tocris Bioscience
SKU: 4289

Tocris Bioscience, part of Bio-Techne | Catalog # 4289

Citations (3)

COA / SDS

Potent S1P1 agonist

Key Product Details

Description:	Potent S1P₁ agonist
Chemical Name:	N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	468.93

View Full Technical Details for RP 001 hydrochloride

Technical Data
Citations

Biological Activity for RP 001 hydrochloride

RP 001 hydrochloride is a potent agonist of S1P₁ receptors (EC₅₀ = 9 pM). Induces internalization and polyubiquitination of S1P₁ in vitro. Selective for S1P₁ over S1P₂ - S1P₄.

Compound Libraries for RP 001 hydrochloride

RP 001 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RP 001 hydrochloride

M. Wt	468.93
Formula	C₂₄H₂₄N₄O₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1781880-34-9
PubChem ID	90488927
InChi Key	ZHPGSGYEFGEZAL-UHFFFAOYSA-N
Smiles	CC(C)OC1=C(C#N)C=C(C2=NC(C3=C(CCC4NCCC(O)=O)C4=CC=C3)=NO2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RP 001 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.25	100

Preparing Stock Solutions for RP 001 hydrochloride

The following data is based on the product molecular weight 468.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.66 mL	21.33 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for RP 001 hydrochloride

References are publications that support the biological activity of the product.

Cahalan Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat.Chem.Biol. 2011 PMID: 21445057