RS 100329 hydrochloride

Name: RS 100329 hydrochloride
Brand: Tocris Bioscience
SKU: 1325

Tocris Bioscience, part of Bio-Techne | Catalog # 1325

Citations (4)

COA / SDS

Potent, subtype-selective α1A antagonist

Key Product Details

Description:	Potent, subtype-selective α_1A antagonist
Chemical Name:	5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	462.89

View Full Technical Details for RS 100329 hydrochloride

Technical Data
Citations

Biological Activity for RS 100329 hydrochloride

RS 100329 hydrochloride is a subtype-selective α_1A-adrenoceptor antagonist (pK_i = 9.6 for human cloned α_1A receptors). Displays 126- and 50-fold selectivity over human α_1B and α_1D receptors respectively. Active in vivo.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 100329 hydrochloride

M. Wt	462.89
Formula	C₂₀H₂₅F₃N₄O₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1215654-26-4
PubChem ID	11340200
InChi Key	CWVABCXVOAVUJL-UHFFFAOYSA-N
Smiles	Cl.CC1=CNC(=O)N(CCCN2CCN(CC2)C2=C(OCC(F)(F)F)C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 100329 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for RS 100329 hydrochloride

The following data is based on the product molecular weight 462.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.80 mL	21.60 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for RS 100329 hydrochloride

References are publications that support the biological activity of the product.

Shannon Kava α_1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 1998 PMID: 9579731
Williams In vitro α₁-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α_1A-adrenoceptor selective antagonists. Br.J.Pharmacol. 1999 PMID: 10369480
Conley The role of α₁-adrenoceptors and 5-HT_1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol. 2001 PMID: 11325795