RS 100329 hydrochloride

Name: RS 100329 hydrochloride
Brand: Tocris Bioscience
SKU: 1325

Tocris Bioscience, part of Bio-Techne | Catalog # 1325

Citations (4)

COA / SDS

Potent, subtype-selective α1A antagonist

Key Product Details

Chemical Name:	5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Purity:	≥99%
Molecular Weight:	462.89 kDa

View Full Technical Details for RS 100329 hydrochloride

Technical Data
Citations

Biological Activity for RS 100329 hydrochloride

RS 100329 hydrochloride is a subtype-selective α_1A-adrenoceptor antagonist (pK_i = 9.6 for human cloned α_1A receptors). Displays 126- and 50-fold selectivity over human α_1B and α_1D receptors respectively. Active in vivo.

Technical Data for RS 100329 hydrochloride

M. Wt	462.89 kDa
Formula	C₂₀H₂₅F₃N₄O₃.HCl
Storage	Store at RT
Purity	≥99%
CAS Number	1215654-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 100329 hydrochloride

Solubility

Soluble Soluble to 100 mM in water

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References for RS 100329 hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Conley et al. The role of α₁-adrenoceptors and 5-HT_1A receptors in the control of the micturition reflex in male anaesthetized rats. Br.J.Pharmacol., 2001;133:61 PMID: 11325795
Shannon Kava et al. α_1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol., 1998;123:1359 PMID: 9579731
Williams et al. In vitro α₁-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α_1A-adrenoceptor selective antagonists. Br.J.Pharmacol., 1999;127:252 PMID: 10369480