RS 504393

Name: RS 504393
Brand: Tocris Bioscience
SKU: 2517
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2517

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Citations (117)

COA / SDS

Highly selective CCR2 chemokine receptor antagonist

Key Product Details

Description:	Highly selective CCR2 chemokine receptor antagonist
Chemical Name:	6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	417.5

View Full Technical Details for RS 504393

Technical Data
Citations / Reviews (1)

Biological Activity for RS 504393

RS 504393 is an extremely selective CCR2 chemokine receptor antagonist (IC₅₀ values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC₅₀ = 330 nM) and ischemia-reperfusion injury in kidneys.

Technical Data for RS 504393

M. Wt	417.5
Formula	C₂₅H₂₇N₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	300816-15-3
PubChem ID	9953769
InChi Key	ODNICNWASXKNNQ-UHFFFAOYSA-N
Smiles	CC1=C(CCN2CCC3(CC2)OC(=O)NC2=C3C=C(C)C=C2)N=C(O1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 504393

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.17	10

Preparing Stock Solutions for RS 504393

The following data is based on the product molecular weight 417.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.95 mL	119.76 mL	239.52 mL
0.5 mM	4.79 mL	23.95 mL	47.90 mL
1 mM	2.40 mL	11.98 mL	23.95 mL
5 mM	0.48 mL	2.40 mL	4.79 mL

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References for RS 504393

References are publications that support the biological activity of the product.

Furuichi CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J.Am.Soc.Nephrol. 2003 PMID: 14514728
Kitagawa Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am.J.Pathol. 2004 PMID: 15215179
Mirzadegan Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 2000 PMID: 10770925