Ruthenium Red

Name: Ruthenium Red
Brand: Tocris Bioscience
SKU: 1439
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1439

(1)

Citations (84)

COA / SDS

Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels

Key Product Details

Description:	Non-selective Ca_V2.1 and 2.2 blocker; also blocks TRPV channels
Chemical Name:	Ammoniated ruthenium oxychloride
Molecular Weight:	786.35

View Full Technical Details for Ruthenium Red

Technical Data
Citations / Reviews (1)

Biological Activity for Ruthenium Red

Ruthenium Red blocks Ca²⁺ uptake and release from mitochondria, and Ca²⁺ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC₅₀ = 14 nM) and voltage-sensitive Ca²⁺ channels to inhibit neurotransmitter release.

Technical Data for Ruthenium Red

M. Wt	786.35
Formula	H₄₂N₁₄O₂Ru₃Cl₆
Storage	Store at RT
CAS Number	11103-72-3
PubChem ID	16218584
InChi Key	JQJSTVUROJELSR-UHFFFAOYSA-H
Smiles	[Ru+2]O[Ru+2]O[Ru+2].N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ruthenium Red

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	7.86	10

Preparing Stock Solutions for Ruthenium Red

The following data is based on the product molecular weight 786.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.72 mL	63.58 mL	127.17 mL
0.5 mM	2.54 mL	12.72 mL	25.43 mL
1 mM	1.27 mL	6.36 mL	12.72 mL
5 mM	0.25 mL	1.27 mL	2.54 mL

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References for Ruthenium Red

References are publications that support the biological activity of the product.

Xu Ruthenium red modifies the cardiac and skeletal muscle Ca²⁺ release channels (ryanodine receptors) by multiple mechanisms. J.Biol.Chem. 1999 PMID: 10551824
Bernardi Pathway for uncoupler-induced calcium efflux in rat liver mitochondria: inhibition by ruthenium red. Biochemistry 1984 PMID: 6202317
Szallasi and Blumberg Vanilloid (capsaicin) receptors and mechanisms. Pharmacol.Rev. 1999 PMID: 10353985
Amann and Maggi Ruthenium red as a capsaicin antagonist. Life Sci. 1991 PMID: 1715010