RWJ 67657

Name: RWJ 67657
Brand: Tocris Bioscience
SKU: 2999

Tocris Bioscience, part of Bio-Techne | Catalog # 2999

Citations (2)

COA / SDS

Potent, selective p38α and p38β inhibitor

Key Product Details

Description:	Potent, selective p38α and p38β inhibitor
Chemical Name:	4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
Purity:	≥98% (HPLC)
Molecular Weight:	425.5

View Full Technical Details for RWJ 67657

Technical Data
Citations

Biological Activity for RWJ 67657

RWJ 67657 is a selective p38α and p38β inhibitor (IC₅₀ values are 1 and 11 μM respectively) that displays no activity at p38γ, p38δ and a range of other kinases. Potently inhibits TNF-α and IL-1β release (IC₅₀ values are 3 and 11 nM respectively) and suppresses HIV-1 replication in T cells in vitro. Displays cardioprotective and anti-inflammatory activity in vivo. Orally active.

Compound Libraries for RWJ 67657

RWJ 67657 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for RWJ 67657

M. Wt	425.5
Formula	C₂₇H₂₄FN₃O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	215303-72-3
PubChem ID	3008319
InChi Key	QSUSKMBNZQHHPA-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4C(N=C(C#CCCO)N2CCCC3=CC=CC=C3)=C2C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RWJ 67657

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.55	100
	ethanol	42.55	100

Preparing Stock Solutions for RWJ 67657

The following data is based on the product molecular weight 425.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.75 mL	23.50 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.24 mL	1.18 mL	2.35 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for RWJ 67657

References are publications that support the biological activity of the product.

See p38 mitogen activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling fowllowing myocardial infarction in the rat. J.Am.Coll.Cardiol. 2004 PMID: 15489104
Wadsworth RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J.Pharm.Exp.Ther. 1999 PMID: 10525088
Muthumani Suppresssion of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor. AIDS 2004 PMID: 15075508