(S)-3,4-DCPG

Name: ( S )-3,4-DCPG
Brand: Tocris Bioscience
SKU: 1302

Tocris Bioscience, part of Bio-Techne | Catalog # 1302

Citations (20)

COA / SDS

Potent and selective mGlu8a agonist

Key Product Details

Description:	Potent and selective mGlu_8a agonist
Alternative Names:	UBP 1109
Chemical Name:	(S)-3,4-Dicarboxyphenylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	239.18

View Full Technical Details for (S)-3,4-DCPG

Technical Data
Citations

Biological Activity for (S)-3,4-DCPG

(S)-3,4-DCPG is a potent, selective mGlu_8a agonist (EC₅₀ = 31 nM). Displays > 100-fold selectivity over mGlu_1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo.

Caged (S)-3,4-DCPG, Racemate and R-enantiomer also available.

Technical Data for (S)-3,4-DCPG

M. Wt	239.18
Formula	C₁₀H₉NO₆
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	201730-11-2
PubChem ID	16062593
InChi Key	IJVMOGKBEVRBPP-ZETCQYMHSA-N
Smiles	N[C@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-3,4-DCPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.92	100
	DMSO	5.98	25

Preparing Stock Solutions for (S)-3,4-DCPG

The following data is based on the product molecular weight 239.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.18 mL	20.90 mL	41.81 mL
5 mM	0.84 mL	4.18 mL	8.36 mL
10 mM	0.42 mL	2.09 mL	4.18 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for (S)-3,4-DCPG

References are publications that support the biological activity of the product.

Thomas (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 2001 PMID: 11166323
Moldrich Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 2001 PMID: 11311902
Thomas Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 1997 PMID: 9455991
Linden Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology 2003 PMID: 12907308