(S)-AMPA

Name: ( S )-AMPA
Brand: Tocris Bioscience
SKU: 0254
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0254

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Citations (83)

COA / SDS

Selective AMPA agonist; active isomer of (RS)-AMPA (Cat. No. 0169)

Key Product Details

Description:	Selective AMPA agonist; active isomer of (RS)-AMPA (Cat. No. 0169)
Chemical Name:	(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Purity:	≥99% (HPLC)
Molecular Weight:	186.17

View Full Technical Details for (S)-AMPA

Technical Data
Citations / Reviews (1)

Biological Activity for (S)-AMPA

(S)-AMPA is an active enantiomer of AMPA (EC₅₀ = 3.5 μM).

NPEC-caged-(S)-AMPA, Inactive Enantiomer and Racemate also available.

Technical Data for (S)-AMPA

M. Wt	186.17
Formula	C₇H₁₀N₂O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	83643-88-3
PubChem ID	158397
InChi Key	UUDAMDVQRQNNHZ-YFKPBYRVSA-N
Smiles	[H][C@@](N)(C(O)=O)CC1=C(C)ON=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-AMPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	9.31	50

Preparing Stock Solutions for (S)-AMPA

The following data is based on the product molecular weight 186.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	10.74 mL	53.71 mL	107.43 mL
2.5 mM	2.15 mL	10.74 mL	21.49 mL
5 mM	1.07 mL	5.37 mL	10.74 mL
25 mM	0.21 mL	1.07 mL	2.15 mL

Molarity Calculator

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Reconstitution Calculator

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References for (S)-AMPA

References are publications that support the biological activity of the product.

Hansen Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 1983 PMID: 6133955
Lauridsen Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 1985 PMID: 2859375
Falch Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 1998 PMID: 9651156