(S)-(-)-Bay K 8644

Name: ( S )-(-)-Bay K 8644
Brand: Tocris Bioscience
SKU: 1546

Tocris Bioscience, part of Bio-Techne | Catalog # 1546

Citations (19)

COA / SDS

CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644

Key Product Details

Description:	Ca_V1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644
Chemical Name:	(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	356.3

View Full Technical Details for (S)-(-)-Bay K 8644

Technical Data
Citations

Biological Activity for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is a L-type Ca²⁺-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

Compound Libraries for (S)-(-)-Bay K 8644

(S)-(-)-Bay K 8644 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (S)-(-)-Bay K 8644

M. Wt	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	98625-26-4
PubChem ID	6603728
InChi Key	ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Smiles	O=C(OC)C1=C(C)NC(C)=C([N+]([O-])=O)[C@H]1[C@]2=CC=CC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(-)-Bay K 8644

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.63	100
	ethanol	35.63	100

Preparing Stock Solutions for (S)-(-)-Bay K 8644

The following data is based on the product molecular weight 356.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.07 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for (S)-(-)-Bay K 8644

References are publications that support the biological activity of the product.

O'Neill and Bolger Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 1988 PMID: 2465070
Ravens and Schopper Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 1692975
Franckowiak The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 1985 PMID: 2412855