(S)-Crizotinib

Name: ( S )-Crizotinib
Brand: Tocris Bioscience
SKU: 6025

Tocris Bioscience, part of Bio-Techne | Catalog # 6025

Citations (1)

COA / SDS

MTH1 inhibitor

Key Product Details

Description:	MTH1 inhibitor
Chemical Name:	3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
Purity:	≥98% (HPLC)
Molecular Weight:	450.34

View Full Technical Details for (S)-Crizotinib

Technical Data
Citations

Biological Activity for (S)-Crizotinib

(S)-Crizotinib is a potent MTH1 inhibitor (IC₅₀ = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for (S)-Crizotinib

(S)-Crizotinib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (S)-Crizotinib

M. Wt	450.34
Formula	C₂₁H₂₂Cl₂FN₅O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1374356-45-2
PubChem ID	56671814
InChi Key	KTEIFNKAUNYNJU-LBPRGKRZSA-N
Smiles	C[C@@H](C1=C(C(F)=CC=C1Cl)Cl)OC2=CC(C3=CN(C4CCNCC4)N=C3)=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-Crizotinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.52	50
	1eq. HCl	9.01	20 with gentle warming

Preparing Stock Solutions for (S)-Crizotinib

The following data is based on the product molecular weight 450.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.44 mL	22.21 mL	44.41 mL
2.5 mM	0.89 mL	4.44 mL	8.88 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
25 mM	0.09 mL	0.44 mL	0.89 mL

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References for (S)-Crizotinib

References are publications that support the biological activity of the product.

Huber Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 2014 PMID: 24695225