(S)-(-)-Sulpiride

Name: ( S )-(-)-Sulpiride
Brand: Tocris Bioscience
SKU: 0895

Tocris Bioscience, part of Bio-Techne | Catalog # 0895

(1)

Citations (51)

COA / SDS

Standard selective D2-like antagonist

Key Product Details

Chemical Name:	(S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Purity:	≥99%
Molecular Weight:	341.42 kDa

View Full Technical Details for (S)-(-)-Sulpiride

Technical Data
Citations / Reviews (1)

Biological Activity for (S)-(-)-Sulpiride

(S)-(-)-Sulpiride is an active enantiomer. Selective D₂-like dopamine antagonist (K_i values are ~ 0.015, ~ 0.013, 1, ~ 45 and ~ 77 μM at D₂, D₃, D₄, D₁ and D₅ receptors respectively).

Racemate also available.

Technical Data for (S)-(-)-Sulpiride

M. Wt	341.42 kDa
Formula	C₁₅H₂₃N₃O₄S
Storage	Store at RT
Purity	≥99%
CAS Number	23672-07-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(-)-Sulpiride

Solubility

Soluble Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO

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References for (S)-(-)-Sulpiride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Seeman and Van Tol DA receptor pharmacology. Trends Pharmacol.Sci., 1994;15:264 PMID: 7940991
Seeman and Van Tol DA D₄ receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol., 1993;233:173 PMID: 8097160