S-Trityl-L-cysteine

Name: S -Trityl-L-cysteine
Brand: Tocris Bioscience
SKU: 2191
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2191

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Citations (41)

COA / SDS

Potent, selective inhibitor of mitotic kinesin Eg5

Key Product Details

Description:	Potent, selective inhibitor of mitotic kinesin Eg5
Alternative Names:	NSC 83265
Chemical Name:	S-(Triphenylmethyl)-L-cysteine
Molecular Weight:	363.47

View Full Technical Details for S-Trityl-L-cysteine

Technical Data
Citations / Reviews (1)

Biological Activity for S-Trityl-L-cysteine

S-Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC₅₀ = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC₅₀ = 140 nM). Induces mitotic arrest in HeLa cells with an IC₅₀ of 700 nM. Displays antitumor activity.

Technical Data for S-Trityl-L-cysteine

M. Wt	363.47
Formula	C₂₂H₂₁NO₂S
Storage	Store at +4°C
CAS Number	2799-07-7
PubChem ID	7271795
InChi Key	DLMYFMLKORXJPO-HXUWFJFHSA-N
Smiles	N[C@@H](C(O)=O)CSC(C2=CC=CC=C2)(C3=CC=CC=C3)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S-Trityl-L-cysteine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.17	50

Preparing Stock Solutions for S-Trityl-L-cysteine

The following data is based on the product molecular weight 363.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.50 mL	27.51 mL	55.03 mL
2.5 mM	1.10 mL	5.50 mL	11.01 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

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Reconstitution Calculator

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References for S-Trityl-L-cysteine

References are publications that support the biological activity of the product.

Brier Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 2004 PMID: 15476401
DeBonis In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 2004 PMID: 15367702