(S)-WAY 100135 dihydrochloride

Name: ( S )-WAY 100135 dihydrochloride
Brand: Tocris Bioscience
SKU: 1253

Tocris Bioscience, part of Bio-Techne | Catalog # 1253

Citations (17)

COA / SDS

Potent and selective 5-HT1A antagonist

Key Product Details

Description:	Potent and selective 5-HT_1A antagonist
Chemical Name:	(S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	468.47

View Full Technical Details for (S)-WAY 100135 dihydrochloride

Technical Data
Citations

Biological Activity for (S)-WAY 100135 dihydrochloride

(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT_1A receptor antagonist (IC₅₀ = 15 nM). Selective over 5-HT_1B, _1C, ₂,α₁, α₂ and D₂ receptors (IC₅₀ > 1000 nM). Centrally active on systemic administration.

Licensing Information

Sold with the permission of Wyeth-Ayerst Research, US Patent 4,988,814

Compound Libraries for (S)-WAY 100135 dihydrochloride

(S)-WAY 100135 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (S)-WAY 100135 dihydrochloride

M. Wt	468.47
Formula	C₂₄H₃₃N₃O₂.2HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	149007-54-5
PubChem ID	6604839
InChi Key	NYZFUZCCDOSQBG-AWEZNQCLSA-N
Smiles	O=C(NC(C)(C)C)[C@@]([C@]3=CC=CC=C3)([H])CN(CC2)CCN2C1=C(OC)C=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-WAY 100135 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.85	100
	water	2.34	5 with gentle warming
	water	4.68	10 with sonication

Preparing Stock Solutions for (S)-WAY 100135 dihydrochloride

The following data is based on the product molecular weight 468.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.67 mL	21.35 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for (S)-WAY 100135 dihydrochloride

References are publications that support the biological activity of the product.

Rodgers and Cole Anxiolytic-like effect of (S)-WAY 100135, a 5-HT_1A receptor antagonist, in the murine elevated plus-maze test. Eur.J.Pharmacol. 1994 PMID: 7813555
Fletcher WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. Eur.J.Pharmacol. 1993 PMID: 8365456
Fletcher Silent 5-HT_1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol.Sci. 1993 PMID: 8122313
Cliffe (S)-N-tert-Butyl-3(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT_1A receptors. J.Med.Chem. 1993 PMID: 8496920