S4

Name: S4
Brand: Tocris Bioscience
SKU: 5577

Tocris Bioscience, part of Bio-Techne | Catalog # 5577

Citations (4)

COA / SDS

High affinity and selective CA IX and CA XII inhibitor

Key Product Details

Description:	High affinity and selective CA IX and CA XII inhibitor
Chemical Name:	4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
Purity:	≥99% (HPLC)
Molecular Weight:	335.38

View Full Technical Details for S4

Technical Data
Citations

Biological Activity for S4

S4 is a high affinity and selective CA IX and CA XII inhibitor (K_i values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

Compound Libraries for S4

S4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for S4

M. Wt	335.38
Formula	C₁₅H₁₇N₃O₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1330061-67-0
PubChem ID	53342705
InChi Key	HGVHSNXRZYOTPD-UHFFFAOYSA-N
Smiles	NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.54	100
	ethanol	6.71	20

Preparing Stock Solutions for S4

The following data is based on the product molecular weight 335.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for S4

References are publications that support the biological activity of the product.

Gieling Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 2012 PMID: 22621623

S4