Sacubitril calcium

Name: Sacubitril calcium
Brand: Tocris Bioscience
SKU: 5772

Tocris Bioscience, part of Bio-Techne | Catalog # 5772

Citations (2)

COA / SDS

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

Key Product Details

Description:	Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names:	AHU 377
Chemical Name:	Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
Purity:	≥98% (HPLC)
Molecular Weight:	430.52

View Full Technical Details for Sacubitril calcium

Technical Data
Citations

Biological Activity for Sacubitril calcium

Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Compound Libraries for Sacubitril calcium

Sacubitril calcium is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Sacubitril calcium

M. Wt	430.52
Formula	C₂₄H₂₈NO₅.½Ca
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1369773-39-6
PubChem ID	91827885
InChi Key	DDLCKLBRBPYKQS-OXXXZDCLSA-L
Smiles	[Ca++].C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1.C[C@@H](C(OCC)=O)C[C@H](NC(CCC([O-])=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sacubitril calcium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.05	100
	ethanol	8.61	20

Preparing Stock Solutions for Sacubitril calcium

The following data is based on the product molecular weight 430.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.61 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Sacubitril calcium

References are publications that support the biological activity of the product.

Ksander Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J.Med.Chem. 1995 PMID: 7752193