SAG 21k

Name: SAG 21k
Brand: Tocris Bioscience
SKU: 5282

Tocris Bioscience, part of Bio-Techne | Catalog # 5282

Citations (4)

COA / SDS

Hedgehog signaling activator; brain penetrant and orally bioavailable

Key Product Details

Description:	Hedgehog signaling activator; brain penetrant and orally bioavailable
Chemical Name:	3-Chloro-4,7-difluoro-N-[[2-methoxy-5-(4-pyridinyl)phenyl]methyl]-N-trans-4-(methylamino)cyclohexyl]benzo[b]thiophene-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	556.07

View Full Technical Details for SAG 21k

Technical Data
Citations

Biological Activity for SAG 21k

SAG 21k is a potent Hedgehog signaling activator (EC₅₀ = 0.4 nM). Orally bioavailable and brain penetrant.

Compound Libraries for SAG 21k

SAG 21k is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SAG 21k

M. Wt	556.07
Formula	C₂₉H₂₈ClF₂N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	946002-48-8
PubChem ID	16678532
InChi Key	YVIFQUJDZSAFKG-UHFFFAOYSA-N
Smiles	COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SAG 21k

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	55.61	100
	ethanol	11.12	20

Preparing Stock Solutions for SAG 21k

The following data is based on the product molecular weight 556.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	8.99 mL	17.98 mL
5 mM	0.36 mL	1.80 mL	3.60 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for SAG 21k

References are publications that support the biological activity of the product.

Brunton Potent agonists of the Hedgehog signaling pathway. Bioorg.Med.Chem.Lett. 2009 PMID: 19500978