Sal 003

Name: Sal 003
Brand: Tocris Bioscience
SKU: 3657

Tocris Bioscience, part of Bio-Techne | Catalog # 3657

Citations (12)

COA / SDS

Cell-permeable inhibitor of eIF2α dephosphorylation

Key Product Details

Description:	Cell-permeable inhibitor of eIF2α dephosphorylation
Chemical Name:	3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity:	≥99% (HPLC)
Molecular Weight:	463.21

View Full Technical Details for Sal 003

Technical Data
Citations

Biological Activity for Sal 003

Sal 003 is a cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.

Compound Libraries for Sal 003

Sal 003 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Sal 003

M. Wt	463.21
Formula	C₁₈H₁₅Cl₄N₃OS
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1164470-53-4
PubChem ID	5717737
InChi Key	TVNBASWNLOIQML-IZZDOVSWSA-N
Smiles	S=C(NC(NC(/C=C/C2=CC=CC=C2)=O)C(Cl)(Cl)Cl)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sal 003

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.32	100

Preparing Stock Solutions for Sal 003

The following data is based on the product molecular weight 463.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.59 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for Sal 003

References are publications that support the biological activity of the product.

Baltiz The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 2007 PMID: 17785458
Costa-Mattioli eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 2007 PMID: 17418795
Raven PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 2008 PMID: 18063576