Sanguinarine chloride

Biological Activity for Sanguinarine chloride

Technical Data for Sanguinarine chloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sanguinarine chloride

References for Sanguinarine chloride

References are publications that support the biological activity of the product.

• Candas D, Lu C, Fan M, Chuang F, Sweeney C, Borowsky A, Li J Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res, 2014;74(24):7498-509. 2014 PMID: 25377473
• Vogt et al. The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem., 2005;280:19078 PMID: 15753082
• Aburai et al. Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem., 2010;74:548 PMID: 20208361
• Adhami et al. Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther., 2004;3:934