Santacruzamate A

Name: Santacruzamate A
Brand: Tocris Bioscience
SKU: 7191

Tocris Bioscience, part of Bio-Techne | Catalog # 7191

Citations (1)

COA / SDS

Highly potent and selective HDAC2 inhibitor

Key Product Details

Chemical Name:	Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
Purity:	≥98%

View Full Technical Details for Santacruzamate A

Technical Data
Citations

Biological Activity for Santacruzamate A

Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC₅₀ = 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC₅₀ = 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC₅₀ >1 μM for HDAC4). Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Santacruzamate A

Formula	C₁₅H₂₂N₂O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1477949-42-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Santacruzamate A

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Santacruzamate A

References are publications that support the biological activity of the product.

Gordon et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature, 2020; PMID: 32353859
Pavlik et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J.Nat.Prod., 2013;76:2026 PMID: 24164245

Santacruzamate A

Tocris Bioscience, part of Bio-Techne | Catalog # 7191

Key Product Details

Biological Activity for Santacruzamate A

Technical Data for Santacruzamate A

Solubility for Santacruzamate A

Dilution Calculator

Reconstitution Calculator

References for Santacruzamate A

Product Documents for Santacruzamate A

COA

Certificate of Analysis

SDS

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