SB 218078

Name: SB 218078
Brand: Tocris Bioscience
SKU: 2560
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2560

(1)

Citations (33)

COA / SDS

Chk1 inhibitor

Key Product Details

Description:	Chk1 inhibitor
Chemical Name:	9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	393.39

View Full Technical Details for SB 218078

Technical Data
Citations / Reviews (1)

Biological Activity for SB 218078

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC₅₀ values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G₂ cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

Compound Libraries for SB 218078

SB 218078 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 218078

M. Wt	393.39
Formula	C₂₄H₁₅N₃O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	135897-06-2
PubChem ID	3387354
InChi Key	OTPNDVKVEAIXTI-UHFFFAOYSA-N
Smiles	O=C1NC(=O)C2=C1C1=C3N(C4CCC(O4)N4C5=C(C=CC=C5)C2=C34)C2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 218078

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.34	100

Preparing Stock Solutions for SB 218078

The following data is based on the product molecular weight 393.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References for SB 218078

References are publications that support the biological activity of the product.

Kawabe G₂ checkpoint abrogators as anticancer drugs. Mol.Cancer Ther. 2004 PMID: 15078995
Chen Checkpoint kinase 1-mediated phosphorylation of cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G₂/M phase cell-cycle arrest and apoptosis. Mol.Carcinogenesis
Jackson An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 2000 PMID: 10676638