SB 258719 hydrochloride

Name: SB 258719 hydrochloride
Brand: Tocris Bioscience
SKU: 2726

Tocris Bioscience, part of Bio-Techne | Catalog # 2726

Citations (3)

COA / SDS

Selective 5-HT7 antagonist

Key Product Details

Description:	Selective 5-HT₇ antagonist
Chemical Name:	3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	374.97

View Full Technical Details for SB 258719 hydrochloride

Technical Data
Citations

Biological Activity for SB 258719 hydrochloride

SB 258719 hydrochloride is a selective 5-HT₇ receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 258719 hydrochloride

SB 258719 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 258719 hydrochloride

M. Wt	374.97
Formula	C₁₈H₃₀N₂O₂S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1217674-10-6
PubChem ID	56972181
InChi Key	UIZKHTBWJSUGOV-UNTBIKODSA-N
Smiles	O=S(C1=CC(C)=CC=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 258719 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.5	100
	DMSO	37.5	100

Preparing Stock Solutions for SB 258719 hydrochloride

The following data is based on the product molecular weight 374.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.33 mL	26.67 mL
5 mM	0.53 mL	2.67 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for SB 258719 hydrochloride

References are publications that support the biological activity of the product.

Thomas Functional characterisation of the human cloned 5-HT₇ receptor (long form); antagonist profile of SB-258719. Br.J.Pharmacol. 1998 PMID: 9720804
Guscott The hypothermic effect of 5-CT in mice is mediated through the 5-HT₇receptor. Neuropharmacology 2003 PMID: 12763096
Forbes (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl)propyl]benzenesulfonamide: the first selective 5-HT₇ receptor antagonist. J.Med.Chem. 1998 PMID: 9513592