SB 265610

Name: SB 265610
Brand: Tocris Bioscience
SKU: 2724

Tocris Bioscience, part of Bio-Techne | Catalog # 2724

Citations (22)

COA / SDS

Potent CXCR2 antagonist

Key Product Details

Description:	Potent CXCR2 antagonist
Chemical Name:	N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	357.16

View Full Technical Details for SB 265610

Technical Data
Citations

Biological Activity for SB 265610

SB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca²⁺ mobilization (IC₅₀ values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 265610

SB 265610 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 265610

M. Wt	357.16
Formula	C₁₄H₉BrN₆O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	211096-49-0
PubChem ID	9841667
InChi Key	SEDUMQWZEOMXSO-UHFFFAOYSA-N
Smiles	O=C(NC3=C(Br)C=CC=C3)NC1=CC=C(C#N)C2=C1NN=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 265610

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.72	100
	ethanol	3.57	10

Preparing Stock Solutions for SB 265610

The following data is based on the product molecular weight 357.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.80 mL	14.00 mL	28.00 mL
5 mM	0.56 mL	2.80 mL	5.60 mL
10 mM	0.28 mL	1.40 mL	2.80 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for SB 265610

References are publications that support the biological activity of the product.

Milatovic Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 PMID: 12753603
Auten Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J.Pharmacol.Exp.Ther. 2001 PMID: 11561067