SB 328437

Name: SB 328437
Brand: Tocris Bioscience
SKU: 3650

Tocris Bioscience, part of Bio-Techne | Catalog # 3650

Citations (22)

COA / SDS

Potent and selective CCR3 antagonist

Key Product Details

Description:	Potent and selective CCR3 antagonist
Chemical Name:	N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	378.38

View Full Technical Details for SB 328437

Technical Data
Citations

Biological Activity for SB 328437

SB 328437 is a potent and selective CCR3 antagonist (IC₅₀ = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD₄, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca²⁺ mobilization (IC₅₀ values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

Compound Libraries for SB 328437

SB 328437 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 328437

M. Wt	378.38
Formula	C₂₁H₁₈N₂O₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	247580-43-4
PubChem ID	10474776
InChi Key	VMFGCGRAIBLAFY-IBGZPJMESA-N
Smiles	O=C(C2=CC=CC3=C2C=CC=C3)N[C@H](C(OC)=O)CC1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 328437

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.84	100

Preparing Stock Solutions for SB 328437

The following data is based on the product molecular weight 378.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for SB 328437

References are publications that support the biological activity of the product.

Mori Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int.Immunol. 2007 PMID: 17804691
Abonyo Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am.J.Physiol.Lung Cell.Mol.Physiol. 2005 PMID: 15863444
White Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 2000 PMID: 10969084