SC 19220

Name: SC 19220
Brand: Tocris Bioscience
SKU: 1206
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1206

Citations (12)

COA / SDS

Selective EP1 receptor antagonist

Key Product Details

Description:	Selective EP₁ receptor antagonist
Chemical Name:	8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide
Purity:	≥99% (HPLC)
Molecular Weight:	331.76

View Full Technical Details for SC 19220

Technical Data
Citations

Biological Activity for SC 19220

SC 19220 is a selective EP₁ receptor antagonist (IC₅₀ = 6.7 μM for inhibition of [³H]-PGE₂ binding to EP₁ transfected COS cells).

Compound Libraries for SC 19220

SC 19220 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SC 19220

M. Wt	331.76
Formula	C₁₆H₁₄ClN₃O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	19395-87-0
PubChem ID	4336830
InChi Key	KNURFLJTOUGOOQ-UHFFFAOYSA-N
Smiles	CC(=O)NNC(=O)N1CC2=C(OC3=CC=C(Cl)C=C13)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 19220

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	8.29	25 with gentle warming
	DMSO	33.18	100

Preparing Stock Solutions for SC 19220

The following data is based on the product molecular weight 331.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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Reconstitution Calculator

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References for SC 19220

References are publications that support the biological activity of the product.

Funk Cloning and expression of a cDNA for the human prostaglandin E receptor EP₁ subtype. J.Biol.Chem. 1993 PMID: 8253813
Sanner Dibenzoxazepine hydrazides as prostaglandin antagonists. Intra-Science Chem.Rept.
Botella Receptor subtypes involved in dual effects induced by prostaglandin E₂ in circular smooth muscle from dog colon. J.Pharmacol.Exp.Ther. 1995 PMID: 7791070