SC 26196

Name: SC 26196
Brand: Tocris Bioscience
SKU: 4189

Tocris Bioscience, part of Bio-Techne | Catalog # 4189

Citations (4)

COA / SDS

Selective fatty acid desaturase 2 inhibitor

Key Product Details

Description:	Selective fatty acid desaturase 2 inhibitor
Chemical Name:	α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Purity:	≥98% (HPLC)
Molecular Weight:	423.55

View Full Technical Details for SC 26196

Technical Data
Citations

Biological Activity for SC 26196

SC 26196 is a selective fatty acid desaturase 2 (FADS2, also known as Δ⁶ desaturase) inhibitor (IC₅₀ = 0.2 μM in vitro). Displays selectivity over FADS1 and stearoly-CoA 9-desaturase (Δ⁵ desaturase and SCD-1/Δ⁹ desaturase, respectively) (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model. Eliminates CSCs from ovarian cancer cell lines and inhibits sphere formation in vitro.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for SC 26196

SC 26196 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SC 26196

M. Wt	423.55
Formula	C₂₇H₂₉N₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	218136-59-5
PubChem ID	9845201
InChi Key	QFYKXKMYVYOUNJ-JBASAIQMSA-N
Smiles	N#CC(C3=CC=CC=C3)(C4=CC=CC=C4)CCCN1CCN(/N=C/C2=CN=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 26196

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.59	25

Preparing Stock Solutions for SC 26196

The following data is based on the product molecular weight 423.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.44 mL	47.22 mL	94.44 mL
1.25 mM	1.89 mL	9.44 mL	18.89 mL
2.5 mM	0.94 mL	4.72 mL	9.44 mL
12.5 mM	0.19 mL	0.94 mL	1.89 mL

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References for SC 26196

References are publications that support the biological activity of the product.

Li Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells. Cell Stem Cell 2017 PMID: 28041894
Hansen-Petrik Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 2002 PMID: 11741743
Zhang A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 2010 PMID: 20086206
Obukowicz Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 1998 PMID: 9765335