SC 51322

Name: SC 51322
Brand: Tocris Bioscience
SKU: 2791
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2791

Citations (15)

COA / SDS

Potent EP1 receptor antagonist

Key Product Details

Description:	Potent EP₁ receptor antagonist
Chemical Name:	8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid hydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	457.93

View Full Technical Details for SC 51322

Technical Data
Citations

Biological Activity for SC 51322

SC 51322 is a potent EP₁ prostanoid receptor antagonist (K_i = 13.8 nM). Displays analgesic properties in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for SC 51322

SC 51322 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SC 51322

M. Wt	457.93
Formula	C₂₂H₂₀ClN₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	146032-79-3
PubChem ID	9933831
InChi Key	CQBVTZDISUKDSX-UHFFFAOYSA-N
Smiles	O=C(NNC(CCSCC4=CC=CO4)=O)N3CC1=CC=CC=C1OC2=CC=C(Cl)C=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 51322

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.79	100
	ethanol	11.45	25

Preparing Stock Solutions for SC 51322

The following data is based on the product molecular weight 457.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.92 mL	21.84 mL
5 mM	0.44 mL	2.18 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for SC 51322

References are publications that support the biological activity of the product.

Hallinan 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid,2-[3-[2-(furanylmethyl)thio]-1-oxopropyl]hydrazide (SC-51322): A potent PGE₂ antagonist and analgesic. Bioorg.Med.Chem.Lett.
Durocher A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture Anal.Biochem. 2000 PMID: 10964415