SCH 202676 hydrobromide

Name: SCH 202676 hydrobromide
Brand: Tocris Bioscience
SKU: 1400
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1400

Citations (48)

COA / SDS

Inhibitor of ligand binding to G-protein-coupled receptors

Key Product Details

Description:	Inhibitor of ligand binding to G-protein-coupled receptors
Chemical Name:	N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	348.26

View Full Technical Details for SCH 202676 hydrobromide

Technical Data
Citations

Biological Activity for SCH 202676 hydrobromide

SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC₅₀ values are 0.1-1.8 μM).

Compound Libraries for SCH 202676 hydrobromide

SCH 202676 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 202676 hydrobromide

M. Wt	348.26
Formula	C₁₅H₁₃N₃S.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	265980-25-4
PubChem ID	9884675
InChi Key	YJYGOWVFDGULLL-UHFFFAOYSA-N
Smiles	C\N=C1SN(C3=CC=CC=C3)C(C2=CC=CC=C2)=N/1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 202676 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.71	25 with gentle warming

Preparing Stock Solutions for SCH 202676 hydrobromide

The following data is based on the product molecular weight 348.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.49 mL	57.43 mL	114.86 mL
1.25 mM	2.30 mL	11.49 mL	22.97 mL
2.5 mM	1.15 mL	5.74 mL	11.49 mL
12.5 mM	0.23 mL	1.15 mL	2.30 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SCH 202676 hydrobromide

References are publications that support the biological activity of the product.

Gao Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 PMID: 15081581
Lewandowicz The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol. 2006 PMID: 16402041
Fawzi SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol. 2001 PMID: 11125021