SCH 202676 hydrobromide

Name: SCH 202676 hydrobromide
Brand: Tocris Bioscience
SKU: 1400
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1400

(1)

Citations (48)

COA / SDS

Inhibitor of ligand binding to G-protein-coupled receptors

Key Product Details

Chemical Name:	N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine hydrobromide
Purity:	≥98%
Molecular Weight:	348.26 kDa

View Full Technical Details for SCH 202676 hydrobromide

Technical Data
Citations / Reviews (1)

Biological Activity for SCH 202676 hydrobromide

SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC₅₀ values are 0.1-1.8 μM).

Technical Data for SCH 202676 hydrobromide

M. Wt	348.26 kDa
Formula	C₁₅H₁₃N₃S.HBr
Storage	Desiccate at +4°C
Purity	≥98%
CAS Number	265980-25-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 202676 hydrobromide

Solubility

Soluble Soluble to 25 mM in DMSO with gentle warming

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References for SCH 202676 hydrobromide

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Fawzi et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. Mol.Pharmacol., 2001;59:30 PMID: 11125021
Gao et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci., 2004;74:3173 PMID: 15081581
Lewandowicz et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br.J.Pharmacol., 2006;147:422 PMID: 16402041