SCH 39166 hydrobromide

Name: SCH 39166 hydrobromide
Brand: Tocris Bioscience
SKU: 2299

Tocris Bioscience, part of Bio-Techne | Catalog # 2299

Citations (15)

COA / SDS

High affinity D1-like antagonist

Key Product Details

Description:	High affinity D₁-like antagonist
Alternative Names:	Ecopipam hydrobromide
Chemical Name:	(6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	394.73

View Full Technical Details for SCH 39166 hydrobromide

Technical Data
Citations

Biological Activity for SCH 39166 hydrobromide

SCH 39166 hydrobromide is a high affinity dopamine D₁/D₅ receptor antagonist; displays K_i values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D₁, D₅, D₂, D₄, 5-HT and α_2a receptors, respectively.

Compound Libraries for SCH 39166 hydrobromide

SCH 39166 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SCH 39166 hydrobromide

M. Wt	394.73
Formula	C₁₉H₂₀ClNO.HBr
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1227675-51-5
PubChem ID	16759171
InChi Key	GAUWIDFICGEZKR-JUOYHRLASA-N
Smiles	Br.CN1CCC2=C(C=C(O)C(Cl)=C2)[C@@H]2[C@@H]1CCC1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SCH 39166 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.47	100

Preparing Stock Solutions for SCH 39166 hydrobromide

The following data is based on the product molecular weight 394.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.67 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for SCH 39166 hydrobromide

References are publications that support the biological activity of the product.

Terry and Katz A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 1994 PMID: 7862841
McQuade In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 1991 PMID: 1826927
Wu DA D₁/D₅ receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D₁/D₅ antagonists. J.Med.Chem. 2005 PMID: 15689153