SD 1008

Name: SD 1008
Brand: Tocris Bioscience
SKU: 3035

Tocris Bioscience, part of Bio-Techne | Catalog # 3035

Citations (8)

COA / SDS

JAK2/STAT3 signaling pathway inhibitor

Key Product Details

Chemical Name:	(1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
Purity:	≥99%
Molecular Weight:	329.35 kDa

View Full Technical Details for SD 1008

Technical Data
Citations

Biological Activity for SD 1008

SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data for SD 1008

M. Wt	329.35 kDa
Formula	C₁₈H₁₉NO₅
Storage	Store at RT
Purity	≥99%
CAS Number	960201-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SD 1008

Solubility

Soluble Soluble to 100 mM in DMSO and to 5 mM in ethanol

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References for SD 1008

References are publications that support the biological activity of the product.

SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Cell Rep, 2020;31(1):107472. 2020 PMID: 32268102
Duan et al. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol., 2007;72:1137 PMID: 17675586