SEN 177

Name: SEN 177
Brand: Tocris Bioscience
SKU: 6979

Tocris Bioscience, part of Bio-Techne | Catalog # 6979

COA / SDS

Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47

Key Product Details

Description:	Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47
Chemical Name:	6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine
Purity:	≥98% (HPLC)
Molecular Weight:	338.39

View Full Technical Details for SEN 177

Technical Data
Citations

Biological Activity for SEN 177

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC₅₀ = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC₅₀ = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.

Technical Data for SEN 177

M. Wt	338.39
Formula	C₁₈H₁₉FN₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2117405-13-5
PubChem ID	91618245
InChi Key	AJIAMIPUWJQSPR-UHFFFAOYSA-N
Smiles	FC=1N=CC(=CC1)C2=CC=CN=C2N3CCC(C4=NN=CN4C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SEN 177

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.77	20
	ethanol	6.77	20

Preparing Stock Solutions for SEN 177

The following data is based on the product molecular weight 338.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.78 mL	73.88 mL	147.76 mL
1 mM	2.96 mL	14.78 mL	29.55 mL
2 mM	1.48 mL	7.39 mL	14.78 mL
10 mM	0.30 mL	1.48 mL	2.96 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SEN 177

References are publications that support the biological activity of the product.

Logtenberg Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat.Med. 2019 PMID: 30833751
Jimenez-Sanchez siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nat.Chem.Biol. 2015 PMID: 25848931