Senktide

Name: Senktide
Brand: Tocris Bioscience
SKU: 1068

Tocris Bioscience, part of Bio-Techne | Catalog # 1068

Citations (52)

COA / SDS

Tachykinin NK3 agonist

Key Product Details

Description:	Tachykinin NK₃ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	841.97

View Full Technical Details for Senktide

Technical Data
Citations

Biological Activity for Senktide

Senktide is a NK₃ tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Technical Data for Senktide

M. Wt	841.97
Formula	C₄₀H₅₅N₇O₁₁S
Single Letter Sequence	DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	106128-89-6
PubChem ID	90479751
InChi Key	UGXWLDUHYDFTIA-QKUYTOGTSA-N
Smiles	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Senktide

Solubility

Soluble to 1mg/ml in PBS (pH 7.4)

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References for Senktide

References are publications that support the biological activity of the product.

Nordquist The tachykinin NK₃ receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 2008 PMID: 18930726
Renzetti Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [³H]senktide. Neuropeptides 1991 PMID: 1712430
Keegan The selective NK receptor agonist senktide excites a subpopulation of DA-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 1992 PMID: 1375857