SF 1670

Name: SF 1670
Brand: Tocris Bioscience
SKU: 5020

Tocris Bioscience, part of Bio-Techne | Catalog # 5020

Citations (6)

COA / SDS

PTPN2 and PTEN inhibitor

Key Product Details

Chemical Name:	N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethylpropanamide
Purity:	≥98%

View Full Technical Details for SF 1670

Technical Data
Citations

Biological Activity for SF 1670

SF 1670 is a PTPN2 and PTEN inhibitor (IC₅₀values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP₃ signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.

Technical Data for SF 1670

Formula	C₁₉H₁₇NO₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	345630-40-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SF 1670

Solubility

Soluble Soluble to 100 mM in DMSO

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References for SF 1670

References are publications that support the biological activity of the product.

Le et al. Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: Its role as a multiphosphatase inhibitor. BMB Rep., 2017;50:329 PMID: 28228214
Li Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood, 2011;117:6702 PMID: 21521784

SF 1670

Tocris Bioscience, part of Bio-Techne | Catalog # 5020

Key Product Details

Biological Activity for SF 1670

Technical Data for SF 1670

Solubility for SF 1670

Dilution Calculator

Reconstitution Calculator

References for SF 1670

Product Documents for SF 1670

COA

Certificate of Analysis

SDS

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