SGC 707

Name: SGC 707
Brand: Tocris Bioscience
SKU: 5367

Tocris Bioscience, part of Bio-Techne | Catalog # 5367

Citations (1)

COA / SDS

Potent and selective allosteric inhibitor of PRMT3

Key Product Details

Chemical Name:	1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
Purity:	≥98%

View Full Technical Details for SGC 707

Technical Data
Citations

Biological Activity for SGC 707

SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC₅₀ = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Decreases H4R3me2a levels in HEK293 cells in vitro.

Negative control also available.

Technical Data for SGC 707

Formula	C₁₆H₁₈N₄O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	1687736-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC 707

Solubility

Soluble Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

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References for SGC 707

References are publications that support the biological activity of the product.

Scheer et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun., 2019;10:19 PMID: 30604761
Kaniskan et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl, 2015;54:5166 PMID: 25728001

SGC 707

Tocris Bioscience, part of Bio-Techne | Catalog # 5367

Key Product Details

Biological Activity for SGC 707

Technical Data for SGC 707

Solubility for SGC 707

Dilution Calculator

Reconstitution Calculator

References for SGC 707

Product Documents for SGC 707

COA

Certificate of Analysis

SDS

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