SGX 523

Tocris Bioscience, part of Bio-Techne | Catalog # 5356

COA / SDS

Selective and potent c-MET kinase inhibitor

Key Product Details

Description:	Selective and potent c-MET kinase inhibitor
Chemical Name:	6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	359.41

View Full Technical Details for SGX 523

Technical Data
Citations

Biological Activity for SGX 523

SGX 523 is a potent and selective c-MET kinase inhibitor (IC₅₀ = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

Compound Libraries for SGX 523

SGX 523 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Technical Data for SGX 523

M. Wt	359.41
Formula	C₁₈H₁₃N₇S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1022150-57-7
PubChem ID	24779724
InChi Key	BCZUAADEACICHN-UHFFFAOYSA-N
Smiles	CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGX 523

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.19	20

Preparing Stock Solutions for SGX 523

The following data is based on the product molecular weight 359.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.91 mL	69.56 mL	139.12 mL
1 mM	2.78 mL	13.91 mL	27.82 mL
2 mM	1.39 mL	6.96 mL	13.91 mL
10 mM	0.28 mL	1.39 mL	2.78 mL

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Reconstitution Calculator

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References for SGX 523

References are publications that support the biological activity of the product.

Buchanan SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 2009 PMID: 19934279