ShK-Dap22

Name: ShK-Dap22
Brand: Tocris Bioscience
SKU: 3220
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3220

(1)

COA / SDS

Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro

Discontinued Product

3220 has been discontinued. View all Voltage-gated Potassium Channel Blockers products.

Key Product Details

Description:	Extremely potent and selective K_V1.3 blocker; suppresses T cell activation in vitro
Purity:	≥95% (HPLC)
Molecular Weight:	4012.7

View Full Technical Details for ShK-Dap22

Technical Data
Citations / Reviews (1)

Biological Activity for ShK-Dap22

ShK-Dap22 is an extremely potent K_V1.3 channel blocker (K_d = 23 pM for mK_V1.3 currents). Selective for K_V1.3 over other mammalian potassium channels (IC₅₀ values are 23, 1800, 10500, 37000 and 39000 pM for mK_V1.3, mK_V1.1, hK_V1.6, mK_V1.4 and rK_V1.2 respectively, and >100000 pM for hK_V1.5, mK_V1.7, hK_V3.1, rK_V3.4 and hK_Ca4). Suppresses T cell activation in vitro (IC₅₀ < 500 pM).

Technical Data for ShK-Dap22

M. Wt	4012.7
Formula	C₁₆₆H₂₆₈N₅₄O₄₈S₇
Single Letter Sequence	RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC (Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	220384-25-8
PubChem ID	122187345
InChi Key	PFWOJTLVNOZSGQ-RIMJLNMDSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for ShK-Dap22

References are publications that support the biological activity of the product.

Robbins Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via K_V1.3 channels. J.Physiol. 2005 PMID: 15677684
Kalman ShK-Dap²², a potent K_V1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 1998 PMID: 9830012

ShK-Dap22

Tocris Bioscience, part of Bio-Techne | Catalog # 3220

Key Product Details

Biological Activity for ShK-Dap22

Technical Data for ShK-Dap22

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for ShK-Dap22

Product Documents for ShK-Dap22

COA

Certificate of Analysis

SDS

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