SI-2 hydrochloride

Name: SI-2 hydrochloride
Brand: Tocris Bioscience
SKU: 5964

Tocris Bioscience, part of Bio-Techne | Catalog # 5964

Citations (1)

COA / SDS

Steroid receptor coactivator 3 (SRC-3) inhibitor

Key Product Details

Description:	Steroid receptor coactivator 3 (SRC-3) inhibitor
Chemical Name:	1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	301.78

View Full Technical Details for SI-2 hydrochloride

Technical Data
Citations

Biological Activity for SI-2 hydrochloride

SI-2 hydrochloride is a potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC₅₀ = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro. Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Technical Data for SI-2 hydrochloride

M. Wt	301.78
Formula	C15H15N5.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1992052-49-9
PubChem ID	121513909
InChi Key	CDYJHORKRVKALB-NWBUNABESA-N
Smiles	CN1C(N/N=C(C2=CC=CC=N2)\C)=NC3=CC=CC=C13.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SI-2 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	15.09	50
	DMSO	6.04	20

Preparing Stock Solutions for SI-2 hydrochloride

The following data is based on the product molecular weight 301.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.63 mL	33.14 mL	66.27 mL
2.5 mM	1.33 mL	6.63 mL	13.25 mL
5 mM	0.66 mL	3.31 mL	6.63 mL
25 mM	0.13 mL	0.66 mL	1.33 mL

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Reconstitution Calculator

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References for SI-2 hydrochloride

References are publications that support the biological activity of the product.

Song Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27084884