Simvastatin

Name: Simvastatin
Brand: Tocris Bioscience
SKU: 1965
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1965

(1)

Citations (27)

COA / SDS

HMG-CoA reductase inhibitor

Key Product Details

Description:	HMG-CoA reductase inhibitor
Chemical Name:	(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate
Purity:	≥98% (HPLC)
Molecular Weight:	418.57

View Full Technical Details for Simvastatin

Technical Data
Citations / Reviews (1)

Biological Activity for Simvastatin

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Compound Libraries for Simvastatin

Simvastatin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Simvastatin

M. Wt	418.57
Formula	C₂₅H₃₈O₅
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	79902-63-9
PubChem ID	54454
InChi Key	RYMZZMVNJRMUDD-HGQWONQESA-N
Smiles	[H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C[C@H](C)C[C@@H]1OC(C(C)(C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Simvastatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.93	50
	ethanol	31.39	75

Preparing Stock Solutions for Simvastatin

The following data is based on the product molecular weight 418.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.19 mL	15.93 mL	31.85 mL
3.75 mM	0.64 mL	3.19 mL	6.37 mL
7.5 mM	0.32 mL	1.59 mL	3.19 mL
37.5 mM	0.06 mL	0.32 mL	0.64 mL

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Reconstitution Calculator

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References for Simvastatin

References are publications that support the biological activity of the product.

Dehnavi Targeting AMPK by statins: A potential therapeutic approach. Drugs 2021 PMID: 33939118
Luttman ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. Cell Rep. 2021 PMID: 34706244
Reinoso Preclinical pharmacokinetics of STAT. Methods Find.Exp.Clin.Pharmacol. 2002 PMID: 12616706
White Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation. J.Clin.Pharmacol. 1999 PMID: 11563401
Kaushal Potential anticancer effects of STAT: fact or fiction? Endothelium 2003 PMID: 12699077
Garrett STAT and bone formation. Curr.Pharm.Des. 2001 PMID: 11405194