SIN-1 chloride

Name: SIN-1 chloride
Brand: Tocris Bioscience
SKU: 0756

Tocris Bioscience, part of Bio-Techne | Catalog # 0756

(1)

Citations (8)

COA / SDS

Water-soluble NO donor

Key Product Details

Chemical Name:	Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Purity:	≥98%
Molecular Weight:	206.63 kDa

View Full Technical Details for SIN-1 chloride

Technical Data
Citations / Reviews (1)

Biological Activity for SIN-1 chloride

This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Technical Data for SIN-1 chloride

M. Wt	206.63 kDa
Formula	C₆H₁₁ClN₄O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	16142-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SIN-1 chloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for SIN-1 chloride

References are publications that support the biological activity of the product.

Nishikawa et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther., 1982;220:183 PMID: 6118429
Maurice and Heslam Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol., 1990;37:671 PMID: 2160060
Siegfried et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther., 1992;260:668 PMID: 1738117
Tanayama et al. Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica, 1974;4:175