SirReal 2

Name: SirReal 2
Brand: Tocris Bioscience
SKU: 5457

Tocris Bioscience, part of Bio-Techne | Catalog # 5457

Citations (1)

COA / SDS

Selective inhibitor of SIRT2

Key Product Details

Description:	Selective inhibitor of SIRT2
Chemical Name:	2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	420.55

View Full Technical Details for SirReal 2

Technical Data
Citations

Biological Activity for SirReal 2

SirReal 2 is a selective SIRT2 inhibitor (IC₅₀ = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Compound Libraries for SirReal 2

SirReal 2 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SirReal 2

M. Wt	420.55
Formula	C₂₂H₂₀N₄OS₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	709002-46-0
PubChem ID	1096292
InChi Key	MENNDDDTIIZDDN-UHFFFAOYSA-N
Smiles	CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SirReal 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.05	100

Preparing Stock Solutions for SirReal 2

The following data is based on the product molecular weight 420.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for SirReal 2

References are publications that support the biological activity of the product.

Rumpf Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 2015 PMID: 25672491