SJ 3149

Name: SJ 3149
Brand: Tocris Bioscience
SKU: 8141

Tocris Bioscience, part of Bio-Techne | Catalog # 8141

COA / SDS

Potent and selective CK1α molecular glue Degrader

Key Product Details

Description:	Potent and selective CK1α molecular glue Degrader
Chemical Name:	3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity:	≥98% (HPLC)
Molecular Weight:	376.37

View Full Technical Details for SJ 3149

Technical Data
Citations

Biological Activity for SJ 3149

SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC₅₀ = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC₅₀ = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC₅₀ = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Technical Data for SJ 3149

M. Wt	376.37
Formula	C₂₀H₁₆N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3026986-17-1
PubChem ID	168511381
InChi Key	AJUZTJBGJWQZFW-UHFFFAOYSA-N
Smiles	O=C1NC(C(CC1)N2C(C3=CC=C(NC4=NOC5=C4C=CC=C5)C=C3C2)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJ 3149

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.64	100

Preparing Stock Solutions for SJ 3149

The following data is based on the product molecular weight 376.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.57 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for SJ 3149

References are publications that support the biological activity of the product.

Nishiguchi Selective CK1a degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat.Commun. 2024 PMID: 38228616