SKF 77434 hydrobromide

Name: SKF 77434 hydrobromide
Brand: Tocris Bioscience
SKU: 1662

Tocris Bioscience, part of Bio-Techne | Catalog # 1662

COA / SDS

Selective D1-like partial agonist

Discontinued Product

1662 has been discontinued. View all Dopamine D1 and D5 Receptor Agonists products.

Key Product Details

Description:	Selective D₁-like partial agonist
Chemical Name:	2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	376.29

View Full Technical Details for SKF 77434 hydrobromide

Technical Data
Citations

Biological Activity for SKF 77434 hydrobromide

SKF 77434 hydrobromide is a selective dopamine D₁-like receptor partial agonist (IC₅₀ values are 19.7 and 2425 nM for binding to D₁-like and D₂-like receptors respectively). Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for SKF 77434 hydrobromide

M. Wt	376.29
Formula	C₁₉H₂₁NO₂.HBr
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	300561-58-4
PubChem ID	11957703
InChi Key	JWQRAXTWDYUBFI-UHFFFAOYSA-N
Smiles	Br.OC1=CC2=C(C=C1O)C(CN(CC=C)CC2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SKF 77434 hydrobromide

References are publications that support the biological activity of the product.

Meyer and Schults DA D₁ receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats. Pharmacol.Biochem.Behav. 1993 PMID: 7903456
Neumeyer Stereoisomeric probes for the D₁ DA receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J.Med.Chem. 1992 PMID: 1533424
Briggs Activation of the 5-HT_1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 1991 PMID: 1687364