SKF 83566 hydrobromide

Name: SKF 83566 hydrobromide
Brand: Tocris Bioscience
SKU: 1586

Tocris Bioscience, part of Bio-Techne | Catalog # 1586

Citations (9)

COA / SDS

Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2

Key Product Details

Description:	Potent and selective D₁-like antagonist; also inhibits adenylyl cyclase 2
Chemical Name:	8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	413.15

View Full Technical Details for SKF 83566 hydrobromide

Technical Data
Citations

Biological Activity for SKF 83566 hydrobromide

SKF 83566 hydrobromide is a potent and selective D₁-like dopamine receptor antagonist (K_i~ 0.56 nM for D₁; K_B = 2 μM for D₂). Also antagonist at the vascular 5-HT₂ receptor (K_i = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Compound Libraries for SKF 83566 hydrobromide

SKF 83566 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKF 83566 hydrobromide

M. Wt	413.15
Formula	C₁₇H₁₈BrNO.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	108179-91-5
PubChem ID	23581817
InChi Key	SDQJYYGODYRPBR-UHFFFAOYSA-N
Smiles	Br.CN1CCC2=CC(Br)=C(O)C=C2C(C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 83566 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.07	5 with gentle warming
	DMSO	41.31	100

Preparing Stock Solutions for SKF 83566 hydrobromide

The following data is based on the product molecular weight 413.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.10 mL	24.20 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for SKF 83566 hydrobromide

References are publications that support the biological activity of the product.

Conley Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J.Pharmacol.Exp.Ther. 2013 PMID: 24008337
Meyer Effects of DA D₁ antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol.Biochem.Behav. 1993 PMID: 8446676
Ohlstein and Berkowitz SCH 23390 and SK&F 83566 are antagonists at vascular DA and serotonin receptors. Eur.J.Pharmacol. 1985 PMID: 3884345
Fritts Locomotor stereotypy produced by dexbenzetimide and scopol. is reduced by SKF 83566, not sulpiride. Pharmacol.Biochem.Behav. 1998 PMID: 9678647