SKF 91488 dihydrochloride

Name: SKF 91488 dihydrochloride
Brand: Tocris Bioscience
SKU: 0512

Tocris Bioscience, part of Bio-Techne | Catalog # 0512

COA / SDS

Histamine N-methyltransferase inhibitor

Discontinued Product

0512 has been discontinued. View all Methyltransferase Inhibitors products.

Key Product Details

Description:	Histamine N-methyltransferase inhibitor
Chemical Name:	4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Molecular Weight:	248.21

View Full Technical Details for SKF 91488 dihydrochloride

Technical Data
Citations

Biological Activity for SKF 91488 dihydrochloride

SKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data for SKF 91488 dihydrochloride

M. Wt	248.21
Formula	C₇H₁₇N₃S.2HCl
Storage	Desiccate at RT
CAS Number	68941-21-9
PubChem ID	11957708
InChi Key	NPLHSMBWWIIWAQ-UHFFFAOYSA-N
Smiles	CN(CCCCSC(=N)N)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SKF 91488 dihydrochloride

References are publications that support the biological activity of the product.

Ohuri Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 1992 PMID: 1534842
Beaven and Shaff New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 1979 PMID: 34400
Beaven and Shaff Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 1979 PMID: 161853
Aiello Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089666

Product Documents for SKF 91488 dihydrochloride

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.