SKF 96365 hydrochloride

Name: SKF 96365 hydrochloride
Brand: Tocris Bioscience
SKU: 1147
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1147

(3)

Citations (28)

COA / SDS

TRPC channel inhibitor; also inhibits store-operated Ca2+ entry

Key Product Details

Description:	TRPC channel inhibitor; also inhibits store-operated Ca²⁺ entry
Chemical Name:	1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	402.92

View Full Technical Details for SKF 96365 hydrochloride

Technical Data
Citations / Reviews (3)

Biological Activity for SKF 96365 hydrochloride

SKF 96365 hydrochloride is a store-operated Ca²⁺ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca²⁺ channels and potassium channels.

Technical Data for SKF 96365 hydrochloride

M. Wt	402.92
Formula	C₂₂H₂₆N₂O₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	130495-35-1
PubChem ID	104955
InChi Key	FWLPKVQUECFKSW-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(CCCOC(CN2C=CN=C2)C2=CC=C(OC)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 96365 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	8.06	20 with gentle warming

Preparing Stock Solutions for SKF 96365 hydrochloride

The following data is based on the product molecular weight 402.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.41 mL	62.05 mL	124.09 mL
1 mM	2.48 mL	12.41 mL	24.82 mL
2 mM	1.24 mL	6.20 mL	12.41 mL
10 mM	0.25 mL	1.24 mL	2.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SKF 96365 hydrochloride

References are publications that support the biological activity of the product.

Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 2009 PMID: 19187978
Singh The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br.J.Pharmacol. 2010 PMID: 20590636
Merritt SK&F96365, a novel inhibitor of receptor-mediated calcium entry. Biochem.J. 1990 PMID: 2173565