SL 327

Name: SL 327
Brand: Tocris Bioscience
SKU: 1969

Tocris Bioscience, part of Bio-Techne | Catalog # 1969

Citations (73)

COA / SDS

Selective inhibitor of MEK1 and MEK2; brain penetrant

Key Product Details

Description:	Selective inhibitor of MEK1 and MEK2; brain penetrant
Chemical Name:	α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Purity:	≥99% (HPLC)
Molecular Weight:	335.35

View Full Technical Details for SL 327

Technical Data
Citations

Biological Activity for SL 327

SL 327 is a selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Technical Data for SL 327

M. Wt	335.35
Formula	C₁₆H₁₂F₃N₃S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	305350-87-2
PubChem ID	9549284
InChi Key	JLOXTZFYJNCPIS-FYWRMAATSA-N
Smiles	N\C(SC1=CC=C(N)C=C1)=C(\C#N)C1=CC=CC=C1C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SL 327

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	16.77	50
	DMSO	33.53	100

Preparing Stock Solutions for SL 327

The following data is based on the product molecular weight 335.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for SL 327

References are publications that support the biological activity of the product.

Atkins The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1998 PMID: 10196568
Scherle Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 2000 PMID: 10969080
Wang Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 2003 PMID: 12490588
Davis The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 2000 PMID: 10844026