SLIGKV-NH2

Name: SLIGKV-NH2
Brand: Tocris Bioscience
SKU: 3010

Tocris Bioscience, part of Bio-Techne | Catalog # 3010

Citations (14)

COA / SDS

PAR2 receptor agonist

Key Product Details

Description:	PAR₂ receptor agonist
Purity:	≥95% (HPLC)
Molecular Weight:	614.78

View Full Technical Details for SLIGKV-NH2

Technical Data
Citations

Biological Activity for SLIGKV-NH2

SLIGKV-NH2 is a protease-activated receptor 2 (PAR₂) agonist (K_i = 9.64 μM and IC₅₀ = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2.

Control Peptide also available.

Technical Data for SLIGKV-NH2

M. Wt	614.78
Formula	C₂₈H₅₄N₈O₇
Single Letter Sequence	SLIGKV (Modifications: Val-6 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	190383-13-2
PubChem ID	10483914
InChi Key	HOWDUIVVWDUEED-WAUHAFJUSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SLIGKV-NH2

Solubility

Soluble to 1mg/ml in water

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References for SLIGKV-NH2

References are publications that support the biological activity of the product.

Hollenberg and Compton International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 2002 PMID: 12037136
Kanke Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [³H]2-furoyl-LIGRL-NH₂, to human PAR2. Br.J.Pharmacol. 2005 PMID: 15765104
Bohm Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 1996 PMID: 8615752