SMBA 1

Name: SMBA 1
Brand: Tocris Bioscience
SKU: 5314

Tocris Bioscience, part of Bio-Techne | Catalog # 5314

Citations (2)

COA / SDS

High affinity and selective activator of Bax

Key Product Details

Chemical Name:	2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity:	≥98%

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Technical Data
Citations

Biological Activity for SMBA 1

SMBA 1 is a high affinity and selective activator of Bax (K_i = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

Technical Data for SMBA 1

Formula	C₂₀H₁₃NO₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	906440-37-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SMBA 1

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming

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References for SMBA 1

References are publications that support the biological activity of the product.

Xin M, Li R, Xie M et al. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014-09-18 PMID: 25230299

SMBA 1

Tocris Bioscience, part of Bio-Techne | Catalog # 5314

Key Product Details

Biological Activity for SMBA 1

Technical Data for SMBA 1

Solubility for SMBA 1

Dilution Calculator

Reconstitution Calculator

References for SMBA 1

Product Documents for SMBA 1

COA

Certificate of Analysis

SDS

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