SMER 28

Name: SMER 28
Brand: Tocris Bioscience
SKU: 4297
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4297

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Citations (11)

COA / SDS

Positive regulator of autophagy

Key Product Details

Description:	Positive regulator of autophagy
Chemical Name:	6-Bromo-N-2-propenyl-4-quinazolinamine
Purity:	≥99% (HPLC)
Molecular Weight:	264.12

View Full Technical Details for SMER 28

Technical Data
Citations / Reviews (1)

Biological Activity for SMER 28

SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Compound Libraries for SMER 28

SMER 28 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for SMER 28

M. Wt	264.12
Formula	C₁₁H₁₀BrN₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	307538-42-7
PubChem ID	1560402
InChi Key	BCPOLXUSCUFDGE-UHFFFAOYSA-N
Smiles	C=CCNC2=NC=NC1=CC=C(Br)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SMER 28

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.41	100

Preparing Stock Solutions for SMER 28

The following data is based on the product molecular weight 264.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.79 mL	18.93 mL	37.86 mL
5 mM	0.76 mL	3.79 mL	7.57 mL
10 mM	0.38 mL	1.89 mL	3.79 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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Reconstitution Calculator

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References for SMER 28

References are publications that support the biological activity of the product.

Sarkar Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 2010 PMID: 17486044
Zhang Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 2016 PMID: 27133794
Renna Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 2010 PMID: 20147746